Having joined Gordon Elliott two seasons ago - and while he failed to win on his first outing for his new handler at Down Royal, he returned to form to finish second in the Lexus Chase before a third placed effort in the Irish Gold Cup at Leopardstown.
Elliott said: "Don Poli and Noble Endeavor both schooled over National fences at the Curragh the other day and went very well.
"Don Poli is a class horse, but he might need the run. He got a bit of heat in his leg before the Gold Cup a few years ago, and we had to leave him off.
"Noble Endeavor is a very good horse. He's a bit in between with the rating he has, and the Grand National could suit him."
Nigel Twiston-Davies has a fine record in the Aintree Grade 3 contest, having saddled six previous winners of the race, including 1998 Grand National hero Earth Summit.
Twiston-Davies said of the latter: "We could have run in the Ladbrokes Trophy at Newbury, but we would like to get some experience over the Grand National fences into him because we hope he could be a horse for the National.
"He ran a fine race in the Scottish Grand National last time and seemed to stay the trip very well.
"He is a smart horse, and if we can get him jumping slickly then we would be hopeful of a good run.
"The Becher looks a good place to start, and we are looking forward to it."
The Cheveley Park Stud-owned 12-year-old is back for another shot - while Moffatt also saddles Just A Par, who makes his debut for the yard having previously been trained by Paul Nicholls.
Moffatt said: "This is Highland Lodge's race full stop. He goes well fresh - we've trained him for this, and his preparation has gone well.
"I'm glad to see the rain has come. He's a 12-year-old now, but his homework has been as good as ever.
"I think it's more about mileage than age, and he has got many miles on the clock.
"Just A Par has been off for a good while, but he was in pre-training for 18 months. It's been a slow and steady build-up.
"It's a big ask for him, but he's done all the work Highland Lodge has done and he's there to do his best."
The field is completed by David Pipe's 2016 Becher hero Vieux Lion Rouge, Colin Tizzard's Ultragold - who won the Topham Chase over the National fences in April - and Warren Greatrex's Kim Muir winner Missed Approach.
Find out more ahead of the 2018 (Grade 3) Becher Chase at Aintree on Saturday.
Published at 12:30 07/12/18